How to use OXERVATE^®

The way OXERVATE^® is prepared and applied may be a change for you. This dosing and administration overview will help you understand how to use OXERVATE.

ADMINISTRATION

Learn how to dose and apply OXERVATE properly

Applying OXERVATE is a multistep process using the materials in the Delivery System Kit and should only be done according to the Instructions for Use.

Dosing

Follow your daily dosing schedule:

It is extremely important that you use OXERVATE exactly as your doctor tells you and complete the full course of treatment for it to be effective.

A drop of OXERVATE and a clock showing 2 hours

When getting ready to apply OXERVATE, remember the
15-minute rule

If you wear contact lenses in your affected eye(s)

Make sure to remove them before using OXERVATE and reinsert 15 minutes after using OXERVATE

If you use any other eye drops

Make sure to use other eye drops at least 15 minutes before or after using OXERVATE

If you use any other eye ointment, gel, or thick eye drop

Make sure to use OXERVATE first, then wait at least 15 minutes before using the other eye ointment, gel, or drop

If you miss a dose of OXERVATE, take your next dose at your scheduled time and do not take an extra dose to make up for the missed one.

Do not use other eye medicines without talking to your doctor.

OXERVATE comes with a Delivery System Kit containing everything you need to use it. Scroll down for more info.

DELIVERY SYSTEM KIT

How to use

A biweekly delivery of OXERVATE includes everything you’ll need for 2 weeks of administration: 2 weekly cartons, each with 7 multiple-dose vials of OXERVATE, and 2 Delivery System Kits, each with 7 days’ worth of supplies. Patients with NK in both eyes will receive 4 weekly cartons in an insulated pack and co-packaged with 4 Delivery System Kits.

Getting OXERVATE

OXERVATE
weekly carton

Icons of a vial, a vial adapter, a pipette, and a disinfectant wipe

7 multiple-dose vials of OXERVATE

Delivery System Kit

7 vial adapters (+1 extra)

42 pipettes (+3 extra)

42 sterile
disinfectant wipes (+3 extra)

Use the Dose Recording Card included in your Delivery System Kit to:

Track your 6 doses per day
Write down the date you start a new weekly supply
Note the time you opened a vial (when you connect the vial adapter to the vial during the week)

Track your 6 doses per day
Write down the date you start a new weekly supply
Note the time you opened a vial (when you connect the vial adapter to the vial during the week)

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Important Safety Information

What is OXERVATE?

OXERVATE is a prescription eye drop solution used to treat a condition called neurotrophic keratitis.

Before you use OXERVATE, tell your doctor about all of your medical conditions, including if you:

have an infection in your eye. If you get an eye infection while using OXERVATE, talk to your doctor right away.

are pregnant or plan to become pregnant. It is not known if OXERVATE will harm your unborn baby.

are breastfeeding or plan to breastfeed. It is not known if OXERVATE passes into your breast milk. Talk to your doctor about the best way to feed your baby if you use OXERVATE.

How should I use OXERVATE?

Use 1 drop of OXERVATE in the affected eye or both eyes if needed, 6 times each day, about 2 hours apart starting in the morning. Continue your treatment for 8 weeks.

If you use any other eye drops, wait at least 15 minutes before or after using OXERVATE. This will help to avoid one eye drop diluting the other eye drop.

If you also use an eye ointment or gel or an eye drop that is thick, use OXERVATE first, and then wait at least 15 minutes before using the other eye ointment, gel, or drops.

If you wear contact lenses in your affected eye or both eyes remove them before using OXERVATE and wait 15 minutes after using OXERVATE before reinserting them.

Do not use other eye medicines without talking to your doctor.

Talk to your doctor first before you stop using OXERVATE.

What should I avoid while using OXERVATE?

Your vision may be blurred for a short time after using OXERVATE. If this happens, wait until your vision clears before you drive or use machines.

What are the possible side effects of OXERVATE?

The most common side effect of OXERVATE is eye pain, enlarged blood vessels in the white of the eyes, swelling of the eye, and increase of tears.

Tell your doctor if you have any side effects that bother you. These are not all the possible side effects of OXERVATE.

For more information about OXERVATE talk to your healthcare provider or pharmacist.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1‑800‑FDA‑1088. You can also contact Dompé U.S. Inc. at 1‑833‑366‑7387.

How to use OXERVATE®