Frequently asked questions

What is OXERVATE®?

OXERVATE is the only prescription eye drop FDA-approved to treat people with neurotrophic keratitis (NK). OXERVATE is approved for use in children 2 years of age and older.

What are the possible side effects of OXERVATE?

The most common side effect of OXERVATE is eye pain, enlarged blood vessels in the white of the eyes, swelling of the eye, and increase of tears. These are not all the possible side effects of OXERVATE. Please see the Important Safety Information below and the Patient Information. Tell your doctor if you have any side effects that bother you.

Can OXERVATE be used by contact lens wearers?

Yes, OXERVATE can be used by contact lens wearers. Contact lenses must be removed from the affected eye or eyes before using OXERVATE and only reinserted 15 minutes after using OXERVATE.

How can I get OXERVATE?

OXERVATE is a prescription medication, so a doctor must prescribe it to a patient. Once a doctor has determined a prescription would be appropriate, a patient may elect to enroll in Dompé CONNECT to Care—a patient support program provided by the manufacturer to help with insurance verification, prior authorizations, financial assistance, and general questions.

Do I need to refrigerate my OXERVATE upon receiving my delivery?

Yes, the OXERVATE weekly carton containing the vials must be refrigerated between 36°F to 46°F (2°C to 8°C) within 5 hours of delivery and stored in the refrigerator for up to 14 days. Do not freeze.

What is neurotrophic keratitis (NK)?

Neurotrophic keratitis may also be referred to as neurotrophic keratopathy or “NK.” NK is an eye disease that is caused by damage to the corneal nerves, leading to the breakdown of the cornea. If NK is not treated, it can lead to a corneal ulcer (which is an open sore in the cornea), scarring, or even vision loss.

What causes neurotrophic keratitis (NK)?

Neurotrophic keratitis (NK) is caused by damage to the corneal nerves that leads to breakdown of the cornea. Many diseases or conditions that can cause nerve damage may lead to NK including, but not limited to, herpes infections of the eye, diabetes, and chronic dry eye disease.

What are the symptoms of neurotrophic keratitis (NK)?

Neurotrophic keratitis (NK) may cause different symptoms in different people, ranging from dryness, sensitivity to light, reduced blinking, or blurry vision. However, some patients may not experience symptoms at all, due to lack of feeling in the cornea.

How can I find out if I have neurotrophic keratitis (NK)?

Neurotrophic keratitis (NK) is a rare disease that requires professional diagnosis. Only an eye care professional will be able to determine if an individual has NK.

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Important Safety Information

What is OXERVATE?

  • OXERVATE is a prescription eye drop solution used to treat a condition called neurotrophic keratitis.

Before you use OXERVATE, tell your doctor about all of your medical conditions, including if you:

  • have an infection in your eye. If you get an eye infection while using OXERVATE, talk to your doctor right away.
  • are pregnant or plan to become pregnant. It is not known if OXERVATE will harm your unborn baby.
  • are breastfeeding or plan to breastfeed. It is not known if OXERVATE passes into your breast milk. Talk to your doctor about the best way to feed your baby if you use OXERVATE.

How should I use OXERVATE?

  • Use 1 drop of OXERVATE in the affected eye or both eyes if needed, 6 times each day, about 2 hours apart starting in the morning. Continue your treatment for 8 weeks.
  • If you use any other eye drops, wait at least 15 minutes before or after using OXERVATE. This will help to avoid one eye drop diluting the other eye drop.
  • If you also use an eye ointment or gel or an eye drop that is thick, use OXERVATE first, and then wait at least 15 minutes before using the other eye ointment, gel, or drops.
  • If you wear contact lenses in your affected eye or both eyes remove them before using OXERVATE and wait 15 minutes after using OXERVATE before reinserting them.
  • Do not use other eye medicines without talking to your doctor.
  • Talk to your doctor first before you stop using OXERVATE.

What should I avoid while using OXERVATE?

  • Your vision may be blurred for a short time after using OXERVATE. If this happens, wait until your vision clears before you drive or use machines.

What are the possible side effects of OXERVATE?

  • The most common side effect of OXERVATE is eye pain, enlarged blood vessels in the white of the eyes, swelling of the eye, and increase of tears.

Tell your doctor if you have any side effects that bother you. These are not all the possible side effects of OXERVATE.

For more information about OXERVATE talk to your healthcare provider or pharmacist.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1‑800‑FDA‑1088. You can also contact Dompé U.S. Inc. at 1‑833‑366‑7387.

Please see full Prescribing Information and Patient Information for OXERVATE.