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For the treatment of all stages of neurotrophic keratitis (NK)

Prescribing Information
hcp-oxe-hero-gradient Close-up illustration of an eye with a representation of an eye with Stage 1 neurotrophic keratitis (NK)

NK is caused by corneal nerve damage1

Corneal nerve damage may lead to a decrease in or total loss of corneal sensitivity—the hallmark of neurotrophic keratitis (NK). This nerve damage impacts ocular surface homeostasis by disrupting the interplay between corneal nerves and corneal epithelial cells, which can lead to epithelial breakdown, including ulceration and, in severe cases, melting and perforation.1,2


Any injury or systemic condition affecting corneal sensory innervation can lead to NK1,3-6

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  • Post-herpetic infection
  • Ocular surgery (eg, LASIK, cataract surgery, corneal transplant, vitrectomy)
  • Chronic ocular surface inflammation or injury
  • Contact lens wear
  • Chronic dry eye disease
  • Topical ophthalmic drug toxicity
  • Chemical and physical burns
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  • Diabetes
  • Multiple sclerosis
  • Vitamin A deficiency
  • Leprosy
  • Amyloidosis
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  • Post-neurosurgical procedures
  • Stroke
  • Neoplasm
  • Aneurysms
  • Degenerative CNS disorders (eg, Alzheimer’s, Parkinson’s)
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  • Riley-Day syndrome
  • Goldenhar-Gorlin syndrome
  • Moebius syndrome
  • Familial corneal hypoesthesia

A patient with 1 or more of these conditions or etiologies should prompt suspicion of neurotrophic keratitis (NK)1,4-6

Presentation & Signs

Patients with NK may not complain of symptoms due to decreased corneal sensitivity4

Signs and symptoms of neurotrophic keratitis (NK) can include4:

An illustration of a dry eye


An illustration of an unblinking eye

Reduced blinking

An illustration of an photophobic eye

(sensitivity to light)

An illustration of an eye with blurry vision

Blurry vision


NK is classified into 3 stages of increasing severity*4

Neurotrophic keratitis (NK) is progressive—and if left untreated can lead to severe corneal damage2

Stage 1

Punctate epithelial
keratitis (PEK)

Stage 2

Persistent epithelial
defect (PED)

Stage 3

Corneal ulcer

NK is a progressive disease and can present at any stage—early diagnosis is essential2,4,5

* Based on the Mackie classification.4

Images show neurotrophic corneal lesions in 3 different patients and do not represent 1 patient’s disease progression.

Access the NK Diagnosis & Staging Tool


When NK is suspected, confirm
with corneal sensitivity testing1

Early diagnosis is critical as progression of NK can often be asymptomatic.2,4,5

Consider corneal sensitivity testing as part of a broader diagnostic workup, including2:

  • Patient medical history
  • Microbiological exam
  • Fluorescein staining
  • Evaluation for systemic conditions

Important: Do not numb the eye when performing staining. Numbing will obscure results of corneal sensitivity testing.

Watch the video to hear from Dr Francis Mah on how he performs corneal sensitivity testing

How to perform corneal sensitivity testing2

  • Qualitative testing: cotton wisp or dental floss
  • Quantitative testing: Cochet-Bonnet esthesiometer
  • Test all 4 quadrants and the center of the cornea
  • Record sensation as normal, reduced, or absent using the healthy eye as reference
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Sign up for resources to help identify and diagnose NK

For US healthcare professionals only.

Important Safety Information


Use with Contact Lens
Contact lenses should be removed before applying OXERVATE because the presence of a contact lens (either therapeutic or corrective) could theoretically limit the distribution of cenegermin-bkbj onto the area of the corneal lesion. Lenses may be reinserted 15 minutes after administration.

Eye Discomfort
OXERVATE may cause mild to moderate eye discomfort such as eye pain during treatment. The patient should be advised to contact their doctor if a more serious eye reaction occurs.


In clinical trials, the most common adverse reaction was eye pain following instillation which was reported in approximately 16% of patients. Other adverse reactions occurring in 1% to 10% of OXERVATE patients and more frequently than in the vehicle-treated patients included corneal deposits, foreign body sensation, ocular hyperemia, ocular inflammation and tearing.


There are no data from the use of OXERVATE in pregnant women to inform any drug associated risks.

The developmental and health benefits of breastfeeding should be considered, along with the mother’s clinical need for OXERVATE, and any potential adverse effects on the breastfed infant from OXERVATE.

Pediatric Use
The safety and effectiveness of OXERVATE have been established in the pediatric population. Use of OXERVATE in pediatric patients 2 years of age and older is supported by evidence from adequate and well-controlled trials of OXERVATE in adults with additional safety data in children.


OXERVATE® (cenegermin-bkbj) ophthalmic solution 0.002% (20 mcg/mL) is indicated for the treatment of neurotrophic keratitis.


Instill one drop of OXERVATE in the affected eye(s), 6 times a day at 2-hour intervals for eight weeks.

To report ADVERSE REACTIONS, contact Dompé U.S. Inc. at 1-833-366-7387 or FDA at 1-800-FDA-1088 or

Please see full Prescribing Information for OXERVATE.

References: 1. Mastropasqua L, Massaro-Giordano G, Nubile M, Sacchetti M. Understanding the pathogenesis of neurotrophic keratitis: the role of corneal nerves. J Cell Physiol. 2017;232:717-724. 2. Sacchetti M, Lambiase A. Diagnosis and management of neurotrophic keratitis. Clin Ophthalmol. 2014;8:571-579. 3. Labetoulle M, Baudouin C, Calonge M, et al. Role of corneal nerves in ocular surface homeostasis and disease. Acta Ophthalmol. 2019;97:137-145. 4. Dua HS, Said DG, Messmer EM, et al. Neurotrophic keratopathy. Prog Retin Eye Res. 2018;66:107-131. 5. Saad S, Abdelmassih Y, Saad R, et al. Neurotrophic keratitis: frequency, etiologies, clinical management and outcomes. Ocul Surf. 2020;18:231-236. 6. Roth M, Dierse S, Alder J, Holtmann C, Geerling G. Incidence, prevalence, and outcome of moderate to severe neurotrophic keratopathy in a German tertiary referral center from 2013 to 2017. Graefes Arch Clin Exp Ophthalmol. 2022;260:1961-1973. 7. Versura P, Giannaccare G, Pellegrini M, Sebastiani S, Campos EC. Neurotrophic keratitis: current challenges and future prospects. Eye Brain. 2018;10:37-45.