

A UNIQUE MOA TARGETS CORNEAL NERVE DAMAGE, THE UNDERLYING CAUSE OF NK1-4
Mechanism of Action
The active ingredient in OXERVATE® is a recombinant form of human nerve growth factor (NGF)1
Cenegermin-bkbj is structurally identical to human NGF protein made in ocular tissues5

Cenegermin-bkbj

Endogenous NGF
Watch a video about how OXERVATE® targets neurotrophic keratitis (NK)



How NGF Works
Nerve growth factor (NGF) is an endogenous protein involved in the differentiation and maintenance of neurons1
Endogenous NGF supports corneal integrity through 3 mechanisms contributing to ocular surface homeostasis (shown in preclinical models)1-4,6:
- Corneal innervation
- Tear secretion
- Epithelial cell growth
As part of ocular surface homeostasis, corneal epithelial cells produce NGF to support sensory nerve health, and sensory nerves produce neuromediators to support corneal epithelial cell health.3,4